CD25 / KIRAVIA Blue 520 / PC61

Product Details
Supplier BioLegend
Catalog #: 102064 (View supplier product page)
Size 100 μg
Price $247.00
Antigen CD25
Clone PC61
Host Rat
Isotype IgG1 λ
Conjugate KIRAVIA Blue 520
Target Species Mouse
Applications FC
Description KIRAVIA Blue 520 anti-mouse CD25
About CD25 and KIRAVIA Blue 520
CD25 The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]
KIRAVIA Blue 520 KIRAVIA Blue 520® (KB520) is a polymeric fluorophore from Sony Biotechnology that has an excitation peak at 497 nm and an emission peak at 520 nm, and is considered an improved alternative to FITC.
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KIRAVIA Blue 520 Excitation and Emission Spectra