PD-1 / Brilliant Violet 510 / EH12.1 (also known as EH12)

Citations: (8)
Product Details
Supplier BD Biosciences
Catalog #: 563076 (View supplier product page)
Size 50 Tests
Price $306.00
Antigen PD-1
Clone EH12.1 (also known as EH12)
Host Mouse
Isotype IgG1 κ
Conjugate Brilliant Violet 510
Target Species Human
Applications FC
Description Hu CD279 (PD-1) BV510 EH12.1 50Tst
About PD-1 and Brilliant Violet 510
PD-1 Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
Brilliant Violet 510 Brilliant™ Violet 510 (BV510) is a green-emitting non-tandem polymer fluorophore that can be excited by the 405 nm Violet laser and collected using a 510/50 bandpass filter. BV510 has an excitation peak at 405 nm and an emission peak at 510 nm, and is similar to StarBright Violet 515 (Bio-Rad). BV510 is most often used in flow cytometry due to its improved signal-to-noise over alternatives like V500 and AmCyan. This dye is part of the Brilliant™ Violet dye line. BV510 and BV480 are the only dyes in the Brilliant™ Violet dye family that are not tandem fluorophores based off the BV421 polymer core, but they have nearly the same maximum excitation.
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Brilliant Violet 510 Excitation and Emission Spectra