Cytokeratin, HMW / DyLight 550 / AE-3

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-33170R (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen Cytokeratin, HMW
Clone AE-3
Host Mouse
Isotype IgG1 κ
Conjugate DyLight 550
Target Species Bovine, Canine, Chicken, Human, Mouse, Primate, Rabbit, Rat
Applications WB, FC, ELISA, IHC-Fr, IHC-P, ICC/IF, IHC
Description This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

DyLight 550 Excitation and Emission Spectra