FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-123-190 (View supplier product page)
	Size	30 µg in 200 µL
	Price	$175.00
	Antigen	CD88
	Clone	REA1206
	Host	Human
	Isotype	IgG1
	Conjugate	Vio Green
	Target Species	Mouse
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
	Description	Clone REA1206 recognizes the mouse CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 is expressed on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on microglia and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist. \| Additional information: Clone REA1206 displays negligible binding to Fc receptors.

	CD88	Enables G protein-coupled receptor activity and complement component C5a receptor activity. Involved in several processes, including complement component C5a signaling pathway; mRNA transcription by RNA polymerase II; and positive regulation of ERK1 and ERK2 cascade. Located in apical part of cell and basolateral plasma membrane. Biomarker of Alzheimer's disease; asthma; chronic obstructive pulmonary disease; rhinitis; and severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Apr 2022]
	Vio Green	Vio®Green from Miltenyi has an excitation peak at 388 nm and an emission peak at 520 nm.

$175.00
Supplier Page

CD88 / Vio Green / REA1206