CD274 / APC / REA1197

Citations: (1)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-122-810 (View supplier product page)
Size 100 tests in 200 µL
Price $335.00
Antigen CD274
Clone REA1197
Host Human
Isotype IgG1
Conjugate APC
Target Species Human
Applications FC, 3D-IF, IF, IHC
Description Clone REA1197 recognizes the human CD274 antigen, also known as programmed cell death 1 ligand 1 (PD-L1), an immune inhibitory receptor ligand which is involved in the costimulatory signal, essential for T cell proliferation and production of interleukin 10 (IL-10) and interferon γ (IFN-γ). | CD274 is expressed on activated T cells, B cells, dendritic cells (DCs), antigen-presenting cells, keratinocytes, monocytes, and various types of tumor cells. In tissues, CD274 is highly expressed in the heart, skeletal muscle, placenta, and lung and weakly expressed in the thymus, spleen, kidney, and liver. | PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. | Additional information: Clone REA1197 displays negligible binding to Fc receptors.
Citations
PMID 11015443
PMID 12893276
PMID 28898057
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APC Excitation and Emission Spectra