CD23 / APC-Vio770 / REA1222

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-124-116 (View supplier product page)
Size 30 tests in 60 µL
Price $155.00
Antigen CD23
Clone REA1222
Host Human
Isotype IgG1
Conjugate APC-Vio770
Target Species Human
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC, Mass Cytometry
Description Clone REA1222 recognizes the human CD23 antigen, which is a 45 kDa type II transmembrane glycoprotein that belongs to the immunoglobulin family. It is expressed on most mature B cells, monocytes, follicular dendritic cells, and at low levels on T cells, Langerhans cells, eosinophils, and platelets. CD23 is thought to play a role in the regulation of B cell activation and IgE response. It is up-regulated upon B cell activation. The proteolytic cleavage of membrane CD23 can result in the release of soluble forms of the antigen (sCD23) with a reported biological activity. | Additional information: Clone REA1222 displays negligible binding to Fc receptors.
About CD23 and APC-Vio770
CD23 The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
APC-Vio770 APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.
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APC-Vio770 Excitation and Emission Spectra