IL-10 R / PE / REA239
IL-10 R / PE / REA239
Citations:
(2)
Product Details
| Supplier | Miltenyi Biotec | |
|---|---|---|
| Catalog #: | 130-121-426 (View supplier product page) | |
| Size | 30 Tests in 60 μl | |
| Price | $109.00 | |
| Antigen | IL-10 R | |
| Clone | REA239 | |
| Host | Cell Line | |
| Isotype | IgG1 | |
| Conjugate | PE | |
| Target Species | Human | |
| Applications | FC | |
| Description | Clone REA239 recognizes the human CD210 antigen, a 90–110 kDa protein, which is also known as IL-10 receptor (IL-10R) alpha subunit. CD210 is expressed on various cell types like monocytes, B cells, large granular lymphocytes, and T cells. The IL-10R protein is structurally related to interferon receptors. Functional IL-10R complexes are tetramers consisting of two IL-10Ralpha polypeptide chains and two IL-10Rbeta chains. Binding of IL-10 to the extracellular domain of IL-10Ralpha activates the IL-10 signal transduction pathway by inducing phosphorylation of STAT1a and STAT3 and by inducing activation of Jak1 and Tyk. IL-10R has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. | Additional information: Clone REA239 displays negligible binding to Fc receptors. | | |
Citations
| PMID 8120391 | ||
|---|---|---|
| PMID 10433356 | ||
| PMID 7759550 | ||
| PMID 27899821 | ||
| Additional Sources |
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Reviews & Ratings
PE Excitation and Emission Spectra
$109.00
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