Integrin beta 7 / Vio Bright FITC / REA441

Citations: (3)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-123-552 (View supplier product page)
Size 100 tests in 200 µL
Price $350.00
Antigen Integrin beta 7
Clone REA441
Host Human
Isotype IgG1
Conjugate Vio Bright FITC
Target Species Human, Mouse
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC, Mass Cytometry
Description Clone REA441 recognizes the human and mouse integrin β7 antigen, a single-pass type I membrane protein which is also known as gut homing receptor β subunit. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin β7 subfamily has two known members (α4β7 and αEβ7) that are expressed primarily by leukocytes and have been implicated in secondary lymphoid structure formation, plasma cells homing to gastrointestinal mucosa, and inflammatory responses. Their ligands: the mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) and E-cadherin are present on the surface of endothelial cells, bone marrow stromal cells, and epithelial cells. Interaction of α4β7 with MAdCAM-1 allows for tissue-specific migration of circulating lymphocytes into the lamina propria and Peyer patches of the gut, whereas αEβ7 retains intraepithelial lymphocytes within the gut epithelium through E-cadherin binding. Integrin β7 is also reported to be involved in the pathogenesis of several diseases such as colitis, diabetic insulitis, and lymphoid malignancies including lymphomatous polyposis in mantle cell lymphoma, thymic lymphoma, and mucosa-associated T cell and B cell non-Hodgkin lymphomas. | Additional information: Clone REA441 displays negligible binding to Fc receptors.
About Integrin beta 7 and Vio Bright FITC
Integrin beta 7 This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Vio Bright FITC Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
Citations
PMID 25015818
PMID 21474670
PMID 1518854
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Vio Bright FITC Excitation and Emission Spectra