FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-123-283 (View supplier product page)
	Size	30 µg in 200 µL
	Price	$95.00
	Antigen	IFN-gamma
	Clone	REA638
	Host	Human
	Isotype	IgG1
	Conjugate	APC
	Target Species	Mouse
	Applications	FC
	Description	Clone REA638 recognizes the mouse interferon-γ (IFN-γ) antigen, a secreted protein which is produced by activated T, B, and NK cells. IFN-γ is a pleiotropic cytokine responsible for macrophage activation and differentiation. It induces transcription of several proinflammatory genes, such as inducible NO synthase, cyclooxygenase-2, and IL-1β, as well as MHC proteins. IFN-γ, in synergy with other cytokines such as TNF-α, inhibits proliferation of normal and transformed cells. Immunomodulatory effects of IFN-γ are exerted on a wide range of cell types expressing the high affinity receptors for IFN-γ. \| Additional information: Clone REA638 displays negligible binding to Fc receptors.

	IFN-gamma	This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

$95.00
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IFN-gamma / APC / REA638