ErbB3 Polyclonal / DyLight 633 /

Product Details
Supplier Stressmarq
Catalog #: SPC-1138D-DY633 (View supplier product page)
Size 100 μl
Price $369.00
Antigen ErbB3
Clone
Host Rabbit
Isotype IgG
Conjugate DyLight 633
Target Species Human, Mouse
Applications WB, Microarray
Description Rabbit Anti-Human ErbB3 Polyclonal
About ErbB3 and DyLight 633
ErbB3 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
DyLight 633 DyLight™ 633 is a red-emitting fluroescent dye that can be excited by the 628 nm laser and collected using a 670/30 nm bandpass filter. DyLight™ 633 has an excitation peak of 638 nm and an emission peak of 658 nm, and is spectrally similar to Alexa Fluor™ 633. DyLight™ 633 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 633 Excitation and Emission Spectra