ErbB2 / Brilliant Ultraviolet 661 / NEU 24.7

Product Details
Supplier BD Biosciences
Catalog #: 749957 (View supplier product page)
Size 50 μg
Price $538.00
Antigen ErbB2
Clone NEU 24.7
Host Mouse
Isotype IgG1
Conjugate Brilliant Ultraviolet 661
Target Species Human
Applications FC
Description Hu Her2/Neu BUV661 NEU 24.7 50ug
About ErbB2 and Brilliant Ultraviolet 661
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Brilliant Ultraviolet 661 Brilliant™ UltraViolet 661 (BUV661) is a red-emitting tandem fluorophore that combines BD Horizon® BUV395 and an acceptor dye. It can be excited by the 355 nm UV laser and collected using a 670/25 bandpass filter. BUV661 has an excitation peak at 498 nm and an emission peak at 657 nm This dye is part of the Brilliant™ UltraViolet dye family, developed and sold by BD Biosciences. This family of dyes uses BUV395 as the donor so that all dyes in the family can be excited by the 355 nm UV laser. Depending on the acceptor, the dyes in this family have different relative brightness ratings.
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Brilliant Ultraviolet 661 Excitation and Emission Spectra