ErbB2 / Brilliant Ultraviolet 563 / 24D2

Product Details
Supplier BD Biosciences
Catalog #: 748746 (View supplier product page)
Size 50 μg
Price $538.00
Antigen ErbB2
Clone 24D2
Host Mouse
Isotype IgG1 κ
Conjugate Brilliant Ultraviolet 563
Target Species Human
Applications FC
Description Hu CD340 (HER-2) BUV563 24D2 50ug
About ErbB2 and Brilliant Ultraviolet 563
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Brilliant Ultraviolet 563 Brilliant™ UltraViolet 563 (BUV563) is a green-emitting tandem fluorophore that combines BD Horizon® BUV395 and an acceptor dye. It can be excited by the 355 nm UV laser and collected using a 585/15 bandpass filter. BUV563 has an excitation peak at 348 nm and an emission peak at 563 nm This dye is part of the Brilliant™ UltraViolet dye family, developed and sold by BD Biosciences. This family of dyes uses BUV395 as the donor so that all dyes in the family can be excited by the 355 nm UV laser. Depending on the acceptor, the dyes in this family have different relative brightness ratings.
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Brilliant Ultraviolet 563 Excitation and Emission Spectra