CD115 / Alexa Fluor 405 / 12-3A3-1B10

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-43362AF405 (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen CD115
Clone 12-3A3-1B10
Host Rat
Isotype IgG2a κ
Conjugate Alexa Fluor 405
Target Species Human
Applications WB, FC, IHC-P, IHC
About CD115 and Alexa Fluor 405
CD115 The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Alexa Fluor 405 Excitation and Emission Spectra