Niemann-Pick C1 / DyLight 680 / 1318A

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-76798FR (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen Niemann-Pick C1
Clone 1318A
Host Rabbit
Isotype IgG
Conjugate DyLight 680
Target Species Human, Mouse, Rat
Applications WB, IHC, IHC-P, Knockout Validated
About Niemann-Pick C1 and DyLight 680
Niemann-Pick C1 This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]
DyLight 680 DyLight™ 680 has an excitation peak at 692 nm and an emission peak at 712 nm, and is spectrally similar to Alexa Fluor™ 680 and Cy5.5. DyLight™ 680 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 680 Excitation and Emission Spectra