MUC-1 / Alexa Fluor 350 / OTI2E3

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-72826AF350 (View supplier product page)
Size 0.1 ml
Price $679.00
Antigen MUC-1
Clone OTI2E3
Host Mouse
Isotype IgG2a
Conjugate Alexa Fluor 350
Target Species Human
Applications WB, IHC
Description Mouse MUC1 antibody [Alexa Fluor 350] detects Human
About MUC-1 and Alexa Fluor 350
MUC-1 This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Alexa Fluor 350 Alexa Fluor™ 350 (AF350, Alexa 350) has an excitation peak at 346 nm and an emission peak at 442 nm, and is spectrally similar in size, brightness and application to AMCA, DyLight™ 350 and CF®350. Alexa 350 is most commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 350 Excitation and Emission Spectra