CD104 / Alexa Fluor 700 / 450-9D

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-65599AF700 (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen CD104
Clone 450-9D
Host Mouse
Isotype IgG1
Conjugate Alexa Fluor 700
Target Species Ferret, Human, Mustelid
Applications WB, FC, ICC/IF, IHC-Fr, IHC
Description NB100-65599 recognizes the human beta4 integrin (also known as CD104), a 205kD glycoprotein which associates with the alpha6 integrin to form the alpha6/beta4 complex. CD104 is expressed on epithelial cells, Schwann cells and various tumour cell lines. NB100-65599 recognizes an extracellular epitope on the CD104 molecule.
About CD104 and Alexa Fluor 700
CD104 Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Alexa Fluor 700 Alexa Fluor™ 700 (AF700, Alexa 700) has an excitation peak at 702 nm and an emission peak at 723 nm, and is spectrally similar to iFluor® 680 (ATT Bioquest) and iFluor® 700 (ATT Bioquest). Alexa 700 is commonly used in Flow Cytometry and is similar in size, brightness and application to iFluor® 700 and Vio® R720.
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Alexa Fluor 700 Excitation and Emission Spectra