LDL Receptor / Alexa Fluor 350 / C7

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-78159AF350 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen LDL Receptor
Clone C7
Host Mouse
Isotype IgG2b
Conjugate Alexa Fluor 350
Target Species Bovine, Human, Porcine, Rat
Applications WB, FC, ELISA, IHC, ICC/IF, IHC-P, IHC-Fr
Description Mouse LDLR antibody [Alexa Fluor 350] detects Human, Rat, Porcine, Bovine
About LDL Receptor and Alexa Fluor 350
LDL Receptor The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Alexa Fluor 350 Alexa Fluor™ 350 (AF350, Alexa 350) has an excitation peak at 346 nm and an emission peak at 442 nm, and is spectrally similar in size, brightness and application to AMCA, DyLight™ 350 and CF®350. Alexa 350 is most commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 350 Excitation and Emission Spectra