CD16 / DyLight 594 / HO-80

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-47954DL594 (View supplier product page)
Size 100 μl
Price $429.00
Antigen CD16
Clone HO-80
Host Mouse
Isotype IgG2a κ
Conjugate DyLight 594
Target Species Human
Applications FC, IF
Description It recognizes CD16 (Fcgamma RIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16, CD16A (Fcgamma RIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fcgamma RIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
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DyLight 594 Excitation and Emission Spectra