Caspase 8 / Alexa Fluor 405 / 90A992

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-56527AF405 (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen Caspase 8
Clone 90A992
Host Mouse
Isotype IgG1
Conjugate Alexa Fluor 405
Target Species Human, Primate
Applications WB, FC, IHC-P, IHC
Description This can be used for detection of the pro-form of Caspase-8.
About Caspase 8 and Alexa Fluor 405
Caspase 8 This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Alexa Fluor 405 Excitation and Emission Spectra