CLEC7A / PE-Cy7 / BD6

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-21513PECY7 (View supplier product page)
Size 0.1 ml
Price $549.00
Antigen CLEC7A
Clone BD6
Host Mouse
Isotype IgG2b
Conjugate PE-Cy7
Target Species Human
Applications FC
Description NBP1-21513 recognizes human Dectin-1, also known as beta-glucan receptor (betaGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (betaGR-A and betaGR-B) and several minor isoforms. betaGR-A and betaGR-B differs by the presence and absence, respectively, of a stalk region. Clone BD6 recognizes betaGR-A only.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

PE-Cy7 Excitation and Emission Spectra