CD8a / Alexa Fluor 594 / 12.C7

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-64021AF594 (View supplier product page)
Size 0.1 ml
Price $509.00
Antigen CD8a
Clone 12.C7
Host Mouse
Isotype IgG1
Conjugate Alexa Fluor 594
Target Species Human, Rabbit
Applications FC, IHC, ICC/IF, IHC-P
Description Recognizes the rabbit CD8 cell surface antigen, expressed by a subset of T lymphocytes with cytotoxic/suppressor activity.
About CD8a and Alexa Fluor 594
CD8a The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]
Alexa Fluor 594 Alexa Fluor™ 594 (AF594, Alexa 594) has an excitation peak at 590 nm and an emission peak at 617 nm, and is spectrally similar to Texas Red (ThermoFisher Scientific), DyLight™ 594 (ThermoFisher Scientific), iFluor® 594 (ATT Bioquest) and iFluor® 610 (ATT Bioquest), CF®594 (Biotium), and ATTO 594 (ATTO-TEC). Alexa 594 is commonly used for flow cytometry,fluorescence microscopy and super-resolution microscopy. It is very bright, photostable, and pH insensitive.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Alexa Fluor 594 Excitation and Emission Spectra