CD28 / Alexa Fluor 750 / 204.12

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-54769AF750 (View supplier product page)
Size 0.1 ml
Price $529.00
Antigen CD28
Clone 204.12
Host Mouse
Isotype IgG2a κ
Conjugate Alexa Fluor 750
Target Species Human, Mouse, Porcine, Primate, Sheep
Applications FC, IF
Description Recognizes a glycoprotein of 44-88kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
About CD28 and Alexa Fluor 750
CD28 The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Alexa Fluor 750 Alexa Fluor™ 750 (AF750, Alexa 750) has an excitation peak at 749 nm and an emission peak at 775 nm, and is spetrally similar to Cy®7 (GE Healthcare), APC-Fire™ 750 (BioLegend), CF®®750 (Biotium), DyLight™ 750 (ThermoFisher Scientific), iFluor® 750 (ATT Bioquest) and iFluor® 790 (ATT Bioquest). Alexa 750 is often used as a tandem fluorophore in flow cytometry or used on its own in fluorescence microscopy, in-vivo fluorescence microscopy or super-resolution microscopy applications.
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Alexa Fluor 750 Excitation and Emission Spectra