Alkaline Phosphatase / Janelia Fluor 549 / HD 11F7

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-76654JF549 (View supplier product page)
Size 0.1 ml
Price $449.00
Antigen Alkaline Phosphatase
Clone HD 11F7
Host Mouse
Isotype IgG2b
Conjugate Janelia Fluor 549
Target Species Human
Applications IHC, IHC-P, IHC-Fr
Description This antibody recognizes both Regan and Nagao isoenzymes of placental alkaline phosphatase (PLAP).
About Alkaline Phosphatase and Janelia Fluor 549
Alkaline Phosphatase This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Janelia Fluor 549 Janelia Fluor® 549 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 549 has an excitation peak at 549 nm and an emission peak at 571 nm.
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Janelia Fluor 549 Excitation and Emission Spectra