Notch 1 / Alexa Fluor 405 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-78292AF405 (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen Notch 1
Clone
Host Rabbit
Isotype IgG
Conjugate Alexa Fluor 405
Target Species Human, Mouse
Applications WB, ICC/IF, IHC-P, IHC
Description Rabbit Notch-1 antibody [Alexa Fluor 405] detects Human, Mouse
About Notch 1 and Alexa Fluor 405
Notch 1 This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra