SHIP1 / Alexa Fluor 350 /
SHIP1 / Alexa Fluor 350 /
Product Details
| Supplier | Bioss | |
|---|---|---|
| Catalog #: | bs-3567R-A350 (View supplier product page) | |
| Size | 100 μl | |
| Price | $468.00 | |
| Antigen | SHIP1 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Alexa Fluor 350 | |
| Target Species | Human, Mouse, Rat | |
| Applications | IHC-P | |
| Description | SHIP1 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated |
About SHIP1 and Alexa Fluor 350
| SHIP1 | This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| Alexa Fluor 350 | Alexa Fluor™ 350 (AF350, Alexa 350) has an excitation peak at 346 nm and an emission peak at 442 nm, and is spectrally similar in size, brightness and application to AMCA, DyLight™ 350 and CF®350. Alexa 350 is most commonly used in flow cytometery and fluorescence microscopy applications. |
Citations
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