RPA2 / Alexa Fluor 750 /
RPA2 / Alexa Fluor 750 /
Product Details
| Supplier | Bioss | |
|---|---|---|
| Catalog #: | bs-4182R-A750 (View supplier product page) | |
| Size | 100 μl | |
| Price | $468.00 | |
| Antigen | RPA2 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Alexa Fluor 750 | |
| Target Species | Human, Mouse, Rat | |
| Applications | IHC-P | |
| Description | RPA32 Polyclonal Antibody, ALEXA FLUOR 750 Conjugated |
About RPA2 and Alexa Fluor 750
| RPA2 | This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017] | |
|---|---|---|
| Alexa Fluor 750 | Alexa Fluor™ 750 (AF750, Alexa 750) has an excitation peak at 749 nm and an emission peak at 775 nm, and is spetrally similar to Cy®7 (GE Healthcare), APC-Fire™ 750 (BioLegend), CF®®750 (Biotium), DyLight™ 750 (ThermoFisher Scientific), iFluor® 750 (ATT Bioquest) and iFluor® 790 (ATT Bioquest). Alexa 750 is often used as a tandem fluorophore in flow cytometry or used on its own in fluorescence microscopy, in-vivo fluorescence microscopy or super-resolution microscopy applications. |
Citations
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