SREBP1 / Alexa Fluor 488 / 2A4

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB600-582AF488 (View supplier product page)
Size 0.1 ml
Price $549.00
Antigen SREBP1
Clone 2A4
Host Mouse
Isotype IgG1 κ
Conjugate Alexa Fluor 488
Target Species Canine, Chicken, Golden Syrian Hamster, Hamster, Human, Monkey, Mouse, Rat
Applications WB
Description Mouse SREBP1 antibody [Alexa Fluor 488] detects Human, Mouse, Rat, Canine, Chicken, Hamster, Monkey, Golden Syrian Hamster
About SREBP1 and Alexa Fluor 488
SREBP1 This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
Alexa Fluor 488 Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A.
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Alexa Fluor 488 Excitation and Emission Spectra