GRP78 / Cy5 /
GRP78 / Cy5 /
Product Details
| Supplier | Bioss | |
|---|---|---|
| Catalog #: | bs-1219R-Cy5 (View supplier product page) | |
| Size | 100 μl | |
| Price | $468.00 | |
| Antigen | GRP78 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Cy5 | |
| Target Species | Human, Mouse, Rat | |
| Applications | IF, IHC | |
| Description | GRP78 Polyclonal Antibody, Cy5 Conjugated |
About GRP78 and Cy5
| GRP78 | The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| Cy5 | Cy5 is an important historical fluorophore from GE Healthcare. It has an excitation peak at 649 nm and an emission peak at 667 nm. Spectrally its similar to Alexa Fluor™ 647. |
Citations
| Additional Sources |
|
|---|
