IL-1 beta / APC / 43N3D8

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-27345APC (View supplier product page)
Size 0.1 ml
Price $419.00
Antigen IL-1 beta
Clone 43N3D8
Host Mouse
Isotype IgG1 κ
Conjugate APC
Target Species Human
Applications FC
Description Mouse IL-1 beta/IL-1F2 antibody [APC] detects Human
About IL-1 beta and APC
IL-1 beta The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]
APC Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

APC Excitation and Emission Spectra