IL-10 R alpha / APC / 1B1.3a

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-63577APC (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen IL-10 R alpha
Clone 1B1.3a
Host Rat
Isotype IgG1
Conjugate APC
Target Species Human (Negative), Mouse
Applications FC
Description NB100-63577 recognizes mouse CDw210a, a cell surface glycoprotein of approximately 110KD, also known as Interleukin-10 receptor 1 (IL-10R1). The epitope recognised by this antibody has been localised to the ligand binding domain within the extracellular region of mouse CDw210a. Mouse CDw210a is expressed by a range of cells including thymocytes, T cells, B cells and monocytes. This clone is reported to neutralize the effects of IL-10 (1).
About IL-10 R alpha and APC
IL-10 R alpha The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
APC Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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APC Excitation and Emission Spectra