Perforin Monoclonal / DyLight 405 / CB5.4

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-97512V (View supplier product page)
Size 0.1 ml
Price $609.00
Antigen Perforin
Clone CB5.4
Host Rat
Isotype IgG2a
Conjugate DyLight 405
Target Species Mouse
Applications WB, IHC-Fr, IHC-P, ICC/IF, FC, IHC
Description Recognizes mouse perforin (region aa 402-534).
About Perforin and DyLight 405
Perforin This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
DyLight 405 DyLight™ 405 has an excitation peak at 400 nm and an emission peak at 420 nm and is spectrally similar to Alexa Fluor™ 405 and Cascade Blue. DyLight™ 405 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 405 Excitation and Emission Spectra