Aminoacylase 1 / APC /
Aminoacylase 1 / APC /
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C717693-1 (View supplier product page) | |
| Size | 1 ml | |
| Price | ||
| Antigen | Aminoacylase 1 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | APC | |
| Target Species | Human, Porcine | |
| Applications | WB | |
| Description | ACY1 / Aminoacylase 1 Antibody (aa2-408, APC) |
About Aminoacylase 1 and APC
| Aminoacylase 1 | This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010] | |
|---|---|---|
| APC | Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm. |
Citations
| Additional Sources |
|
|---|
