GSAP / HRP /
GSAP / HRP /
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C714844-1 (View supplier product page) | |
| Size | 1 ml | |
| Price | ||
| Antigen | GSAP | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | HRP | |
| Target Species | Human | |
| Applications | WB | |
| Description | GSAP / PION Antibody (aa616-854, HRP) |
About GSAP and HRP
| GSAP | Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010] |
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Citations
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