FluoroFinder

	Supplier	LifeSpan
	Catalog #:	LS-C704243-100 (View supplier product page)
	Size	100 μl
	Price
	Antigen	CBL
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Cy3
	Target Species	Human
	Applications	WB
	Description	c-CBL Antibody (aa558-816, Cy3)

	CBL	This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
	Cy3	Cy3 is an important historical fluorophore from GE Healthcare. It has an excitation peak at 554 nm and an emission peak at 568 nm. Spectrally its similar to Alexa Fluor™ 555.

	Additional Sources

CBL / Cy3 /