Perforin / Cy3 /
Perforin / Cy3 /
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C700415-100 (View supplier product page) | |
| Size | 100 μl | |
| Price | ||
| Antigen | Perforin | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Cy3 | |
| Target Species | Human | |
| Applications | WB | |
| Description | PRF1 / Perforin Antibody (aa32-316, Cy3) |
About Perforin and Cy3
| Perforin | This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017] | |
|---|---|---|
| Cy3 | Cy3 is an important historical fluorophore from GE Healthcare. It has an excitation peak at 554 nm and an emission peak at 568 nm. Spectrally its similar to Alexa Fluor™ 555. |
Citations
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