Immunodeficiency Virus gp95 / DyLight 488 / SU1-30

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-64378G (View supplier product page)
Size 0.125 ml
Price $499.00
Antigen Immunodeficiency Virus gp95
Clone SU1-30
Host Mouse
Isotype IgG1
Conjugate DyLight 488
Target Species Virus
Applications WB, FC
Description NB100-64378 specifically recognizes the relatively conserved E60 peptide (amino acid sequence SSWKQRNRWEWRPDF) located within the V3 region of FIV (Feline Immunodeficiency Virus) envelope glycoprotein SU,gp95. The primary receptor for FIV infection of cats has been identified as the T-cell activation antigen CD134 which, along with CXC chemokine receptor 4 (CXCR4), facilitates the infection of CD4+ primary target cells, resulting in a depletion in the CD4+ population. Studies have shown that the V3 loop of SU,gp95 is a major immunogenic domain, suggested to contain the main determinants for the binding of FIV SU,gp95 to CXCR4.(3) Clone SU1-30 has been shown to inhibit the sCD134-activated entry of both clade B and clade C FIV strains.(1) NB100-64378 does not recognize Feline Leukaemia Virus, Feline Herpes Virus type 1, Feline Coronavirus or Feline Calicivirus. Removal of Sodium Azide is recommended prior to use in functional studies.
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DyLight 488 Excitation and Emission Spectra