alpha 2 Macroglobulin / Biotin /
alpha 2 Macroglobulin / Biotin /
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C685348-200 (View supplier product page) | |
| Size | 200 μl | |
| Price | ||
| Antigen | alpha 2 Macroglobulin | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Biotin | |
| Target Species | Rat | |
| Applications | WB | |
| Description | A2M / Alpha-2-Macroglobulin Antibody (aa818-1048, Biotin) |
About alpha 2 Macroglobulin and Biotin
| alpha 2 Macroglobulin | The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016] |
|---|
Citations
| Additional Sources |
|
|---|
