PTPN12 / HRP /
PTPN12 / HRP /
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C671032-100 (View supplier product page) | |
| Size | 100 μg | |
| Price | ||
| Antigen | PTPN12 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | HRP | |
| Target Species | Human | |
| Applications | ||
| Description | PTP-PEST / PTPN12 Antibody (HRP) |
About PTPN12 and HRP
| PTPN12 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] |
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Citations
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