Collagen IV alpha 1 / DyLight 350 / 1043

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-97716UV (View supplier product page)
Size 0.1 ml
Price $549.00
Antigen Collagen IV alpha 1
Clone 1043
Host Mouse
Isotype IgG1
Conjugate DyLight 350
Target Species Human
Applications WB, FC, IHC-Fr, IHC-P, ICC/IF, IHC
Description 1043 recognizes type IV collagen in the extracellular - basement membranes of normal and pathological human tissues.
About Collagen IV alpha 1 and DyLight 350
Collagen IV alpha 1 This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
DyLight 350 DyLight™ 350 has an excitation peak of 353 nm and an emission peak of 432 nm. It is spectrally similar to Alexa Fluor™ 350, iFluor® 350, AMCA, and Thioflavin T. DyLight™ 350 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 350 Excitation and Emission Spectra