GSTM1 / DyLight 550 /
GSTM1 / DyLight 550 /
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C756623 (View supplier product page) | |
| Size | 100 μg | |
| Price | ||
| Antigen | GSTM1 | |
| Clone | ||
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | DyLight 550 | |
| Target Species | Human | |
| Applications | FC | |
| Description | GSTM1 Antibody (DY550) |
About GSTM1 and DyLight 550
| GSTM1 | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| DyLight 550 | DyLight™ 550 has an excitation peak at 562 nm and an emission peak at 576 nm and is spectrally similar to Alexa Fluor™ 546, Alexa Fluor™ 555, Cy3 and TRITC. DyLight™ 550 is most commonly used in flow cytometery and fluorescence microscopy applications. |
Citations
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