CD35 / APC / E11
CD35 / APC / E11
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C751041 (View supplier product page) | |
| Size | 100 Tests | |
| Price | $365.00 | |
| Antigen | CD35 | |
| Clone | E11 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | APC | |
| Target Species | Human | |
| Applications | FC, ICC, IHC-Fr, IHC-P, IP, WB | |
| Description | CR1 / CD35 Antibody (clone E11, APC) |
About CD35 and APC
| CD35 | This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020] | |
|---|---|---|
| APC | Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm. |
Citations
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