CCR6 / FITC / G034E3
CCR6 / FITC / G034E3
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 353411 (View supplier product page) | |
| Size | 25T | |
| Price | $124.00 | |
| Antigen | CCR6 | |
| Clone | G034E3 | |
| Host | Mouse | |
| Isotype | IgG2b κ | |
| Conjugate | FITC | |
| Target Species | Cynomolgus macaque, Human, Rhesus macaque | |
| Applications | FC | |
| Description | FITC anti-human CD196 (CCR6) |
About CCR6 and FITC
| CCR6 | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| FITC | Fluorescein isothiocyanate (FITC) has an excitation peak at 495 nm and an emission peak at 519 nm. The name FITC is a misnomer in that the isothiocyanate is a reactive form of this dye. Once FITC is conjugated to an antibody, it is simply Fluorescein conjugated. FITC is one of the most widely used dyes for fluorescent applications, therefore most instruments come standard with a 488 nm laser and FITC filter set up. FITC is commonly conjugated to secondary antibodies and used in applications such as flow cytometry, immunocytochemistry, and immunohistochemistry. FITC is relatively dim, sensitive to photobleaching and it is susceptible to changes is pH. There are better performing alternatives to FITC, like Vio®Bright 515, Alexa Fluor™ 488, iFluor® 488, CF®488A and DY-488. FITC is a long-time generic dye with no sole manufacturer or trademark. |
Images
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Human peripheral lymphocytes were stained with CD19 PE and CD196 (clone G034E3) FITC (top) or mouse IgG2b, κ FITC isotype control (bottom). |
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Citations
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Reviews & Ratings
FITC Excitation and Emission Spectra
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