CD86 / APC-Cy7 / GL-1

Citations: (33)
Product Details
Supplier BioLegend
Catalog #: 105030 (View supplier product page)
Size 100 μg
Price $288.00
Antigen CD86
Clone GL-1
Host Rat
Isotype IgG2a κ
Conjugate APC-Cy7
Target Species Mouse
Applications FC
Description APC/Cyanine7 anti-mouse CD86
About CD86 and APC-Cy7
CD86 This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
APC-Cy7 APC-Cy7 (APC-Cyanine 7) has an excitation peak at 650 nm and an emission peak at 785 nm, and is spectrally similar to APC-CF®750 (Biotium), APC-H7 (BD Biosciences), APC-eFluor™ 780 (Thermo Fisher Scientific), APC-Vio®770 (Miltenyi Biotec) and APC-Fire™ 750 (BioLegend). This dye is a member of the Cyanine® dye family, a trademark of GE heathcare.
Citations
PMID 17537839
PMID 22710245
PMID 25505280
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APC-Cy7 Excitation and Emission Spectra