CD25 / Spectral Red / 3C7
CD25 / Spectral Red / 3C7
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C350176 (View supplier product page) | |
| Size | 100 μg | |
| Price | ||
| Antigen | CD25 | |
| Clone | 3C7 | |
| Host | Rat | |
| Isotype | IgG2b | |
| Conjugate | Spectral Red | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | IL2RA / CD25 Antibody (clone 3C7, SPRD) |
About CD25 and Spectral Red
| CD25 | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] |
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Citations
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