MAP3K8 / Unconjugated / 3D9
MAP3K8 / Unconjugated / 3D9
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C340483 (View supplier product page) | |
| Size | 100 μl | |
| Price | ||
| Antigen | MAP3K8 | |
| Clone | 3D9 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | WB | |
| Description | MAP3K8 / TPL2 Antibody (aa277-461, clone 3D9) |
About MAP3K8 and Purified
| MAP3K8 | This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] |
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Citations
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