SAV1 / Unconjugated / 2B7
SAV1 / Unconjugated / 2B7
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C339313 (View supplier product page) | |
| Size | 100 μl | |
| Price | ||
| Antigen | SAV1 | |
| Clone | 2B7 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | WB | |
| Description | SAV1 / WW45 Antibody (aa167-383, clone 2B7) |
About SAV1 and Purified
| SAV1 | WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012] |
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Citations
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