KLHL12 / Unconjugated / 4C10
KLHL12 / Unconjugated / 4C10
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C338677 (View supplier product page) | |
| Size | 100 μl | |
| Price | ||
| Antigen | KLHL12 | |
| Clone | 4C10 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | WB | |
| Description | KLHL12 Antibody (aa177-405, clone 4C10) |
About KLHL12 and Purified
| KLHL12 | This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
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Citations
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