CD45 / V500 / D058-1283

Citations: (3)
Product Details
Supplier BD Biosciences
Catalog #: 561489 (View supplier product page)
Size 50 Tests
Price $310.00
Antigen CD45
Clone D058-1283
Host Mouse
Isotype IgG1 κ
Conjugate V500
Target Species Baboon, Cynomolgus macaque, Rhesus macaque
Applications FC
Description NHP CD45 Horizon V500 D058-1283 50Tst
About CD45 and V500
CD45 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
V500 V500 (Horizon V500) from BD Biosciences has an excitation peak at 415 nm and an emission peak at 500 nm. It is spectrally similar to AmCyan.
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V500 Excitation and Emission Spectra