CD4 V450 (RPA-T4, Mouse) - Reactivity: Human
Product Details
| Description |
The RPA-T4 monoclonal antibody specifically binds to CD4, a 59 kDa single-chain transmembrane glycoprotein that is expressed on T-helper/inducer cell populations. CD4 is also expressed on thymocyte subsets and at lower levels on monocytes and macrophages. CD4 functions as a co-receptor in MHC class II-restricted antigen-induced T cell activation and as a receptor for human immunodeficiency viruses (HIV). This antibody binds to the D1 domain (CDR1 and CDR3 epitopes) of the CD4 antigen and reacts with approximately 80% of thymocytes and 45% of peripheral blood lymphocytes. RPA-T4 is capable of blocking HIV-1, gp120, and inhibits syncytium formation. |
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| Conjugate | V450 | |
| Clone | RPA-T4 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | BD Biosciences | |
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About CD4
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]
About V450
V450 (Horizon V450) from BD Biosciences has an excitation peak at 406 nm and an emission peak at 450 nm. It is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), Vio®Blue® (Miltenyi Biotec), Alexa Fluor™ 405 (ThermoFisher Scientific), Cascade Blue® (ThermoFisher Scientific), Pacific Blue (ThermoFisher Scientific), and ATTO 425 (ATTO-Tec)
V450 (Horizon V450) from BD Biosciences has an excitation peak at 406 nm and an emission peak at 450 nm. It is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), Vio®Blue® (Miltenyi Biotec), Alexa Fluor™ 405 (ThermoFisher Scientific), Cascade Blue® (ThermoFisher Scientific), Pacific Blue (ThermoFisher Scientific), and ATTO 425 (ATTO-Tec)
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