DUX4 / ATTO 633 / P2B1
DUX4 / ATTO 633 / P2B1
Product Details
| Supplier | LifeSpan | |
|---|---|---|
| Catalog #: | LS-C231542 (View supplier product page) | |
| Size | 100 μg | |
| Price | ||
| Antigen | DUX4 | |
| Clone | P2B1 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | ATTO 633 | |
| Target Species | Human | |
| Applications | IF, IHC, IHC-P, WB | |
| Description | DUX4 Antibody (C-Terminus, clone P2B1, Atto 633) |
About DUX4 and ATTO 633
| DUX4 | This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] | |
|---|---|---|
| ATTO 633 | ATTO 633 from ATTO-TEC has an excitation peak at 629 nm and an emission peak at 657 nm. ATTO 633 belongs to a new generation of fluorescent labels for the red spectral region. Characteristic features of the label are strong absorption, high fluorescence quantum yield, and high thermal and photo-stability. Thus ATTO 633 is highly suitable for single-molecule detection applications and high-resolution microscopy such as SIM, STED etc. Additionally the dye highly qualifies to be applied in flow cytometry (FACS), fluorescence in-situ hybridization (FISH) and many more. In common with most ATTO-labels, absorption and fluorescence are independent of pH, at least in the range of pH 2 to 11, used in typical applications. ATTO 633 is a cationic dye. After coupling to a substrate the label carries a net electrical charge of +1. The label is moderately hydrophilic. |
Citations
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